N-Boc-4-pentyne-1-amine

N-Boc-4-pentyne-1-amine is a PROTAC linker, which refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine can be used in the synthesis of the PROTAC MG-277 (HY-130122) [1]. N-Boc-4-pentyne-1-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[151978-50-6]

UNSPSC

12352211

Hazard Statement

H314

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-boc-4-pentyne-1-amine.html

Purity

99.01

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(OC(C)(C)C)NCCCC#C

Molecular Formula

C10H17NO2

Molecular Weight

183.25

Precautions

H314

References & Citations

[1]Yang J, et al. Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders. J Med Chem. 2019 Oct 21.