Emodin

Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2) . Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].

Product Specifications

CAS Number

[518-82-1]

Product Name Alternative

Frangula emodin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

11β-HSD; Autophagy; Casein Kinase; SARS-CoV

Type

Natural Products

Related Pathways

Anti-infection; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Emodin.html

Purity

99.39

Solubility

Acetone : 10.87 mg/mL (ultrasonic) |DMSO : 5.41 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL (ultrasonic)

Smiles

O=C1C2=C(C=C(C)C=C2O)C(C3=CC(O)=CC(O)=C31)=O

Molecular Formula

C15H10O5

Molecular Weight

270.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Tin-Yun Ho, et al. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 2007 May;74 (2) :92-101.|[2]Ying Feng, et al. Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. Br J Pharmacol. 2010 Sep;161 (1) :113-26.|[3]Stefania Sarno, et al. Toward the rational design of protein kinase casein kinase-2 inhibitors. Pharmacol Ther. Feb-Mar 2002;93 (2-3) :159-68.