6-Aminonicotinic acid

6-Aminonicotinic acid is a GABAA receptor agonist with Ki value of 4.4 nM. 6-Aminonicotinic acid can be formed via electrocatalytic synthesis at silver cathodes. 6-Aminonicotinic acid has a variety of biological properties, such as protein synthesis inhibitor, vitamin B3 agonist, and modulating agent in chemotherapy[1][2].

Product Specifications

CAS Number

[3167-49-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/6-aminonicotinic-acid.html

Purity

99.86

Solubility

DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C1=CN=C(N)C=C1

Molecular Formula

C6H6N2O2

Molecular Weight

138.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Petersen JG, et al. Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABA (A) receptor agonists. Eur J Med Chem. 2014 Sep 12;84:404-16.|[2]Armando Gennaro, et al., Electrocatalytic synthesis of 6-aminonicotinic acid at silver cathodes under mild conditions, Electrochemistry Communications, Volume 6, Issue 7, 2004.