ICA-27243
ICA-27243 is a selective, potent and orally active KCNQ2/Q3 potassium channel opener with an EC50 of 0.38 μM. ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 has antiepileptic and anticonvulsant effects[1][2].
Product Specifications
CAS Number
325457-89-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ica-27243.html
Purity
99.27
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C(F)=C1)F)NC2=CC=C(N=C2)Cl
Molecular Formula
C12H7ClF2N2O
Molecular Weight
268.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Wickenden AD, et al. N- (6-chloro-pyridin-3-yl) -3,4-difluoro-benzamide (ICA-27243) : a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73 (3) :977-86.|[2]Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2 (6) :481-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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