ICA-27243

ICA-27243 is a selective, potent and orally active KCNQ2/Q3 potassium channel opener with an EC50 of 0.38 μM. ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 has antiepileptic and anticonvulsant effects[1][2].

Product Specifications

CAS Number

[325457-89-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ica-27243.html

Purity

99.27

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(C(F)=C1)F)NC2=CC=C(N=C2)Cl

Molecular Formula

C12H7ClF2N2O

Molecular Weight

268.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Wickenden AD, et al. N- (6-chloro-pyridin-3-yl) -3,4-difluoro-benzamide (ICA-27243) : a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73 (3) :977-86.|[2]Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2 (6) :481-4.