ICA-27243
ICA-27243 is a selective, potent and orally active KCNQ2/Q3 potassium channel opener with an EC50 of 0.38 μM. ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 has antiepileptic and anticonvulsant effects[1][2].
Product Specifications
CAS Number
325457-89-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ica-27243.html
Purity
99.27
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C(F)=C1)F)NC2=CC=C(N=C2)Cl
Molecular Formula
C12H7ClF2N2O
Molecular Weight
268.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Wickenden AD, et al. N- (6-chloro-pyridin-3-yl) -3,4-difluoro-benzamide (ICA-27243) : a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73 (3) :977-86.|[2]Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2 (6) :481-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
IHULGALS1ARC6HISLY20UG 20 µg
LGALS1 Active Recombinant Protein C-6His Tag Lyophilized 20ug
Sign In for Pricing
View Details 
orb2702873-01 1 mg
TMEFF1 Biosimilar (Bluefin patent TMEFF1 / Tomoregulin-1 Reference Antibody)
Sign In for Pricing
View Details orb2702873-02 5 mg
TMEFF1 Biosimilar (Bluefin patent TMEFF1 / Tomoregulin-1 Reference Antibody)
Sign In for Pricing
View Details orb2702873-03 100 mg
TMEFF1 Biosimilar (Bluefin patent TMEFF1 / Tomoregulin-1 Reference Antibody)
Sign In for Pricing
View Details