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Ac-DEVD-CMK (TFA)

Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK TFA significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK TFA can be used in a variety of experimental approaches to inhibit apoptosis[1][2][3].

Product Specifications

Product Name Alternative

Caspase-3 Inhibitor III (TFA)

UNSPSC

12352209

Target

Apoptosis; Caspase

Type

Peptides

Related Pathways

Apoptosis

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ac-devd-cmk-tfa.html

Purity

99.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClCC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O

Molecular Formula

C23H32ClF3N4O13

Molecular Weight

664.97

References & Citations

[1]Hung KC, et al. Citrate-Induced p85α⁻PTEN Complex Formation Causes G2/M Phase Arrest in Human Pharyngeal Squamous Carcinoma Cell Lines. Int J Mol Sci. 2019 Apr 29;20 (9) :2105.|[2]Nam EJ, et al. Syndecan-1 limits the progression of liver injury and promotes liver repair in acetaminophen-induced liver injury in mice. Hepatology. 2017 Nov;66 (5) :1601-1615.|[3]Lu Cai, et al. Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes. 2002 Jun;51 (6) :1938-48.|[4]M M Mocanu, et al. Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. Br J Pharmacol. 2000 May;130 (2) :197-200.|[5]M Blanco-Molina, et al. Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-kappaB independent pathway. Chem Biol. 2001 Aug;8 (8) :767-78.|[6]Eon Jeong Nam, et al. Syndecan-1 limits the progression of liver injury and promotes liver repair in acetaminophen-induced liver injury in mice. Hepatology. 2017 Nov;66 (5) :1601-1615.|[7]Eon Jeong Nam, et al. Syndecan-1 limits the progression of liver injury and promotes liver repair in acetaminophen-induced liver injury in mice. Hepatology. 2017 Nov;66 (5) :1601-1615.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Scientific Category

Peptides

Clinical Information

No Development Reported

Citation 01

J Agric Food Chem. 2025 Aug 27;73 (34) :21296-21308.|PLoS Pathog. 2024 Jul 22;20 (7) :e1012408.|Exp Neurol. 2024 Mar:373:114678.

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