N6022
N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase (GSNOR) inhibitor with IC50 of 8 nM.
Product Specifications
CAS Number
1208315-24-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GSNOR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/N6022.html
Concentration
10mM
Purity
99.66
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
OC(CCC1=CC=C(N1C2=CC=C(C(N)=O)C=C2C)C(C=C3)=CC=C3N4C=CN=C4)=O
Molecular Formula
C24H22N4O3
Molecular Weight
414.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Sun X, et al. Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement. Bioorg Med Chem Lett. 2011 Jun 15;21 (12) :3671-5.|[2]Colagiovanni DB, et al. A nonclinical safety and pharmacokinetic evaluation of N6022: a first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma. Regul Toxicol Pharmacol. 2012 Feb;62 (1) :115-24.|[3]Green LS, et al. Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Biochemistry. 2012 Mar 13;51 (10) :2157-68.|[4]Thomas M. Raffay, et al. Methods of treating respiratory disorders. Patent. US 20170209419 A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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