N6022

N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase (GSNOR) inhibitor with IC50 of 8 nM.

Product Specifications

CAS Number

[1208315-24-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GSNOR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/N6022.html

Concentration

10mM

Purity

99.66

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

OC(CCC1=CC=C(N1C2=CC=C(C(N)=O)C=C2C)C(C=C3)=CC=C3N4C=CN=C4)=O

Molecular Formula

C24H22N4O3

Molecular Weight

414.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Sun X, et al. Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement. Bioorg Med Chem Lett. 2011 Jun 15;21 (12) :3671-5.|[2]Colagiovanni DB, et al. A nonclinical safety and pharmacokinetic evaluation of N6022: a first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma. Regul Toxicol Pharmacol. 2012 Feb;62 (1) :115-24.|[3]Green LS, et al. Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Biochemistry. 2012 Mar 13;51 (10) :2157-68.|[4]Thomas M. Raffay, et al. Methods of treating respiratory disorders. Patent. US 20170209419 A1.