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Saroglitazar (magnesium)

Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively.

Product Specifications

CAS Number

[1639792-20-3]

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Saroglitazar-Magnesium.html

Purity

98.85

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CCO([Mg+2]1(O(CC)[C@H](C([O-]1)=O)CC2=CC=C(OCCN3C(C)=CC=C3C4=CC=C(SC)C=C4)C=C2)[O-]C5=O)[C@H]5CC6=CC=C(OCCN7C(C)=CC=C7C8=CC=C(SC)C=C8)C=C6

Molecular Formula

C50H56MgN2O8S2

Molecular Weight

901.42

References & Citations

[1]Jain MR, et al. Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering effects in preclinical models. Pharmacol Res Perspect. 2015 Jun;3 (3) :e00136.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 4

Isoform

PPARα; PPARγ

Citation 01

BMC Complement Med Ther. 2021 Apr 10;21 (1) :118.|Patent. US20210275504A1.|Acta Pharm Sin B. 2025 Sep 19.|Ann Med. 2025 Dec;57 (1) :2497112.|Cell Biol Toxicol. 2021 Apr;37 (2) :293-311.|iScience. 2025 Apr 3;28 (5) :112344.|Medicina (Kaunas) . 2025 Jun 26;61 (7) :1157.|Patent. US20190388398A1.|Sci Adv. 2025 Sep 26;11 (39) :eads3731.|SSRN. 2024 May 30.

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