L17E
Product Specifications
UNSPSC Description
L17E, an endosomolytic peptide, is a cationic amphiphilic peptide with specific membrane lytic activity for late endosomes (LEs). L17E diminishes the TS5-p45 induced apoptosis in a dose-dependent manner. L17E is endocytosed into cells and trafficked to LEs. Within the acidic environment of LEs, L17E perturbs and lyses the LE membrane, leading to disruption of LE membrane and release of LE content to the cytosol. L17E is used to investigate the role of the endosomal protein trafficking pathway[1].
Target Antigen
Others
Type
Peptides
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/l17e.html
Purity
99.80
Solubility
H2O : ≥ 100 mg/mL
Smiles
CC(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC2=CC=CC=C12)NC([C@H]([C@H](CC)C)N)=O)=O)CC(C)C)=O)[C@@H](C)O)=O)C)=O)CC(C)C)=O)CCCCN)=O)CC3=CC=CC=C3)=O)CC(C)C)=O)=O)CCCCN)=O)CC4=CN=CN4)=O)C)=O)C)=O)CCCCN)=O)CC5=CN=CN5)=O)CCC(O)=O)=O)C)=O)CCCCN)=O)CCC(N)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CO)=O)CCCCN)=O)C(N)=O)C
Molecular Weight
2859.42
References & Citations
[1]Dogan Can Kirman, et al. Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis. Cell Death Dis. 2022 Feb 23;13(2):172.|[2]Dogan Can Kirman, et al. Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis. Cell Death Dis. 2022 Feb 23;13(2):172.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P4121/L17E-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P4121/L17E-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1898254-09-5
Available Sizes
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