Xanthohumol D

Xanthohumol D, isolated from hops, is an inhibitor of quinone reductase-2 (QR-2) with the IC50 value of 110 μM, and binds to the active site of QR-2. Xanthohumol D shows antiproliferative activity on human cancer cell lines in vitro[1][2].

Product Specifications

CAS Number

[274675-25-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xanthohumol-d.html

Purity

99.21

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=C(OC)C=C(O)C(CC(O)C(C)=C)=C1O)/C=C/C2=CC=C(O)C=C2

Molecular Formula

C21H22O6

Molecular Weight

370.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Choi Y, et al. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Anal Chem. 2011 Feb 1;83 (3) :1048-52.|[2]Tronina T, et al. Fungal metabolites of xanthohumol with potent antiproliferative activity on human cancer cell lines in vitro. Bioorg Med Chem. 2013 Apr 1;21 (7) :2001-6.