BMS-741672
BMS-741672 is a selective and orally active CCR2 antagonist with an IC50 of 1.1 nM. BMS-741672 shows >700-fold selective for CCR2 than CCR5[1].
Product Specifications
CAS Number
1004757-96-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bms-741672.html
Smiles
CC(N[C@H]1[C@@H](N2C([C@H](CC2)NC3=NC=NC4=C3C=C(C(F)(F)F)C=C4)=O)CC[C@H](C1)N(C)C(C)C)=O
Molecular Formula
C25H33F3N6O2
Molecular Weight
506.56
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Michael G Yang, et al. Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672. ACS Med Chem Lett. 2019 Jan 16;10 (3) :300-305.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CCR2; CCR5
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TL300076V 500 µL Each
ZNF385D Human shRNA Lentiviral Particle (Locus ID 79750)
Sign In for Pricing
View Details