VU 6008667
VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration[1].
Product Specifications
CAS Number
[2092923-21-0]
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu-6008667.html
Purity
99.53
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=CC=CC=C2[C@]3(C4=CC=C(Cl)C(C)=C4)N1CCN3C(C5=CC(F)=C(F)C=C5)=O
Molecular Formula
C24H17ClF2N2O2
Molecular Weight
438.85
References & Citations
[1]McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27 (6) :1356-1359.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR5
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
036736-HRP 200 µL
HOXD4, CT (HOXD4, HOX4B, Homeobox protein Hox-D4, Homeobox protein HHO.C13, Homeobox protein Hox-4B, Homeobox protein Hox-5.1) (Azide free) (HRP) discontinued
Ask
View Details MBS6378659-01 0.1 mL
FKBP4 (FK506-binding Protein 4, Peptidyl-prolyl cis-trans Isomerase FKBP4, PPIase FKBP4, Rotamase, HSP-binding Immunophilin, HBI, FKBP52 Protein, 52kD FK506-binding Protein, 52kD FKBP, FKBP-52, 59kD Immunophilin, FKBP59, p59 Protein, FKBP-4, FKBP52) APC
Ask
View Details