MSC 2032964A

MSC 2032964A is an orally active, selective inhibitor for apoptosis signal-regulating kinase 1 (ASK1) with IC50 of 96 nM. MSC 2032964A preserves the visual responses in EAE mice model and exhibits potency in ameliorating the neuroinflammation[1].

Product Specifications

CAS Number

[1124381-43-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

MAP3K; p38 MAPK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/msc-2032964a.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CN=C1)NC2=NN3C(NC4CC4)=CC(C(F)(F)F)=CC3=N2

Molecular Formula

C16H13F3N6O

Molecular Weight

362.31

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Guo X, et al., Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol Med. 2010 Dec;2 (12) :504-15.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAP3K5/ASK1

Available Sizes

Curated Selection

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