MSC 2032964A
MSC 2032964A is an orally active, selective inhibitor for apoptosis signal-regulating kinase 1 (ASK1) with IC50 of 96 nM. MSC 2032964A preserves the visual responses in EAE mice model and exhibits potency in ameliorating the neuroinflammation[1].
Product Specifications
CAS Number
[1124381-43-6]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MAP3K; p38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/msc-2032964a.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CN=C1)NC2=NN3C(NC4CC4)=CC(C(F)(F)F)=CC3=N2
Molecular Formula
C16H13F3N6O
Molecular Weight
362.31
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Guo X, et al., Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol Med. 2010 Dec;2 (12) :504-15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP3K5/ASK1
Available Sizes
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