MSC 2032964A
MSC 2032964A is an orally active, selective inhibitor for apoptosis signal-regulating kinase 1 (ASK1) with IC50 of 96 nM. MSC 2032964A preserves the visual responses in EAE mice model and exhibits potency in ameliorating the neuroinflammation[1].
Product Specifications
CAS Number
[1124381-43-6]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MAP3K; p38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/msc-2032964a.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CN=C1)NC2=NN3C(NC4CC4)=CC(C(F)(F)F)=CC3=N2
Molecular Formula
C16H13F3N6O
Molecular Weight
362.31
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Guo X, et al., Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol Med. 2010 Dec;2 (12) :504-15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP3K5/ASK1
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Human Collagen Triple Helix Repeat Containing Protein 1, CTHRC1 ELISA KIT
Human Collagen Triple Helix Repeat Containing Protein 1, CTHRC1 ELISA KIT
Human Collagen Triple Helix Repeat Containing Protein 1, CTHRC1 ELISA KIT
Human Collagen Triple Helix Repeat Containing Protein 1, CTHRC1 ELISA KIT