LY379268
LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC50 values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3) . LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects[1][2].
Product Specifications
CAS Number
191471-52-0
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly379268.html
Purity
99.84
Solubility
0.1 M NaOH : 200 mg/mL (ultrasonic; adjust pH to 8 with NaOH) |H2O : 2 mg/mL (ultrasonic; adjust pH to 10 with NaOH)
Smiles
O=C([C@]1(N)CO[C@@]2([H])[C@H](C(O)=O)[C@@]12[H])O
Molecular Formula
C7H9NO5
Molecular Weight
187.15
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR2; mGluR3
Available Sizes
Frequently Asked Questions
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