Omeprazole-d3-1

Omeprazole-d3-1 is the deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) [3].

Product Specifications

CAS Number

[934293-92-2]

Product Name Alternative

H 16868-d3-1

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Autophagy; Bacterial; Phospholipase; Proton Pump

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Field of Research

Cancer; Infection; Metabolic Disease

Purity

95.09

Solubility

10 mM in DMSO|DMF : ≥ 30mg/mL|DMSO : ≥ 30mg/mL|Ethanol : ≥ 5mg/mL

Smiles

CC(C(OC)=C(C=N1)C)=C1CS(C(NC2=C3[2H])=NC2=C([2H])C([2H])=C3OC)=O

Molecular Formula

C17H16D3N3O3S

Molecular Weight

348.43

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32 (8) :821-7.|[3]Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37 (1) :145-50.|[4]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35 (1) :1322-1330.