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Farletuzumab ecteribulin

Farletuzumab ecteribulin (MORAb-202) is an antibody-drug conjugate (ADC), consisting of the humanized anti-human folate receptor alpha (FRA) antibody Farletuzumab conjugated via reduced interchain disulfide bonds to Mal-PEG2-Val-Cit-PAB-eribulin. Farletuzumab ecteribulin has a agent-to-antibody ratio of 4.0. Farletuzumab ecteribulin is highly cytotoxic to FRA-positive cells in vitro. Farletuzumab ecteribulin has potent antitumor activity.

Product Specifications

CAS Number

2407465-18-1

Product Name Alternative

MORAb-202

UNSPSC

12352203

Target

Antibody-Drug Conjugates (ADCs)

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/farletuzumab-ecteribulin.html

Purity

99.40

Solubility

H2O

Smiles

[Farletuzumabecteribulin]

Molecular Weight

149000 (average)

References & Citations

[1]Keiji Furuuchi, et al. Antibody-drug conjugate MORAb-202 exhibits long-lasting antitumor efficacy in TNBC PDx models. Cancer Sci. 2021 Jun;112 (6) :2467-2480.|[2]Xin Cheng, et al. MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FRα Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Mol Cancer Ther. 2018 Dec;17 (12) :2665-2675.

Shipping Conditions

Dry Ice

Storage Conditions

-80°C, protect from light

Scientific Category

ADC Related

Clinical Information

Phase 2

Available Sizes

Frequently Asked Questions

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