DC-LC3in-D5
Product Specifications
UNSPSC Description
DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 binds with LC3B. DC-LC3in-D5 disrupts the LC3B-LBP2 interaction with an IC50 of 200 nM. DC-LC3in-D5 may contribute to anti-HCV or combination researchs in cancer through inhibiting autophagy[1].
Target Antigen
Atg8/LC3; Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dc-lc3in-d5.html
Solubility
DMSO : 35.71 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1/C(C(CC(C2=C(Cl)C(Cl)=CC=C2)C1)=O)=C/NCCN3CCOCC3
Molecular Weight
397.30
References & Citations
[1]Shijie Fan, et al. Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-141882/DC-LC3in-D5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-141882/DC-LC3in-D5-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2868312-73-4
Available Sizes
Curated Selection
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