DC-LC3in-D5

DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 binds with LC3B. DC-LC3in-D5 disrupts the LC3B-LBP2 interaction with an IC50 of 200 nM. DC-LC3in-D5 may contribute to anti-HCV or combination researchs in cancer through inhibiting autophagy[1].

Product Specifications

CAS Number

[2868312-73-4]

UNSPSC

12352005

Target

Atg8/LC3; Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dc-lc3in-d5.html

Purity

98.62

Solubility

DMSO : 35.71 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1/C(C(CC(C2=C(Cl)C(Cl)=CC=C2)C1)=O)=C/NCCN3CCOCC3

Molecular Formula

C19H22Cl2N2O3

Molecular Weight

397.30

References & Citations

[1]Shijie Fan, et al. Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60 (50) :26105-26114.