Aderbasib
Product Specifications
UNSPSC Description
Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2+ breast cancer, gliomas, et al[1].
Target Antigen
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aderbasib.html
Purity
99.44
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(CC1)CCN1C2=CC=CC=C2)[C@H]([C@H](C3)C(NO)=O)N(CC43CC4)C(OC)=O
Molecular Weight
416.47
References & Citations
[1]Lois Witters, et al. Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor. Cancer Res. 2008 Sep 1;68(17):7083-9.|[2]Fei Yuan, et al. ADAM17 is an essential attachment factor for classical swine fever virus. PLoS Pathog. 2021 Mar 8;17(3):e1009393.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10293/Aderbasib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10293/Aderbasib-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
791828-58-5
Available Sizes
Curated Selection
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