TLR6 rabbit pAb

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations. [provided by RefSeq, Jan 2011],

Product Specifications

Background

UniProt

Q9Y2C9

Swiss Prot

Q9Y2C9

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Protein of TLR6

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF

Dilution

IHC: 1:200-500

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cell membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, phagosome membrane ; Single-pass type I membrane protein . Membrane raft . Golgi apparatus . Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus (PubMed:16880211) . .