Camptothecin
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].
Product Specifications
CAS Number
7689-03-4
Product Name Alternative
Campathecin; (S) - (+) -Camptothecin; CPT
UNSPSC
12352005
Hazard Statement
H301, H340
Target
ADC Payload; Antibiotic; Apoptosis; Fungal; Influenza Virus; MicroRNA; Topoisomerase
Type
Natural Products
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Campathecin.html
Purity
99.86
Solubility
1M NaOH : 10 mg/mL (ultrasonic; adjust pH to 11 with NaOH) |DMSO : 6.25 mg/mL (ultrasonic)
Smiles
O=C1C2=C([C@@](O)(CC)C(OC2)=O)C=C(N1C3)C(C3=C4)=NC5=C4C=CC=C5
Molecular Formula
C20H16N2O4
Molecular Weight
348.36
Precautions
H301, H340
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Camptothecins; Topo I
Available Sizes
Frequently Asked Questions
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