ART-IN-1
ART-IN-1 (compound 7) is a selective PARP inhibitor with IC50s of 19, 22, 2.4, >100, 1.1 μM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively[1].
Product Specifications
CAS Number
[2418014-98-7]
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/art-in-1.html
Purity
98.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(OC1=CC2=C(C(NC3=C2C=CS3)=O)C=C1)C
Molecular Formula
C14H13NO2S
Molecular Weight
259.32
References & Citations
[1]Maksimainen MM, et al. Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs. Bioorg Med Chem. 2021;52:116511.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP10; PARP14; PARP15; PARP2; TNKS2/PARP5B
Available Sizes
Curated Selection
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