VU0453595
Product Specifications
UNSPSC Description
VU0453595 is a highly selective, systemically active M1 positive allosteric modulator (PAM, EC50=2140 nM) for the research of schizophrenia[1][2].
Target Antigen
mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0453595.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(CC2=CC=C(C3=CN(C)N=C3)C=C2F)CC4=NC=CC=C41
Molecular Weight
322.34
References & Citations
[1]A Ghoshal, et al. Potentiation of M<sub>1</sub> Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model. Neuropsychopharmacology. 2016 Jan;41(2):598-610.|[2]Sean P Moran, et al. M<sub>1</sub>-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition. Neuropsychopharmacology. 2018 Jul;43(8):1763-1771.|[3]Xiaohui Lv, et al. M<sub>1</sub> muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons. Neuropharmacology. 2017 May 15;118:209-222.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120023/VU0453595-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120023/VU0453595-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1432436-13-9
Available Sizes
Curated Selection
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