RFX6 rabbit pAb
The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis. [provided by RefSeq, Sep 2010],
Product Specifications
Background
Gene ID
222546
UniProt
Q8HWS3
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human RFX6 AA range: 264-314
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA, IHC
Validated Applications
WB,ELISA,IHC
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES13408-1.pdf
Subcellular Location
Nucleus .
Gene ID (Human)
222546
SwissProt (Human)
Q8HWS3
Available Sizes
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