PND-1186
PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis[1].
Product Specifications
CAS Number
1061353-68-1
Product Name Alternative
VS-4718; SR-2516
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; FAK
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PND-1186.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : ≥ 34 mg/mL
Smiles
O=C(NC)C1=CC=CC=C1NC2=CC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2C(F)(F)F
Molecular Formula
C25H26F3N5O3
Molecular Weight
501.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Tanjoni I, et al. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther. 2010 May 15;9 (10) :764-77.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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