PND-1186

PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis[1].

Product Specifications

CAS Number

[1061353-68-1]

Product Name Alternative

VS-4718; SR-2516

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; FAK

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PND-1186.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : ≥ 34 mg/mL

Smiles

O=C(NC)C1=CC=CC=C1NC2=CC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2C(F)(F)F

Molecular Formula

C25H26F3N5O3

Molecular Weight

501.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Tanjoni I, et al. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther. 2010 May 15;9 (10) :764-77.