Artesunate
Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1) .
Product Specifications
CAS Number
[88495-63-0]
UNSPSC
12352005
Hazard Statement
H302+H312+H332
Target
Ferroptosis; Parasite; STAT; Virus Protease
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Artesunate.html
Purity
99.89
Solubility
7.5% Sodium bicarbonate : 2 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 83.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C(O[C@H]1[C@H](C)[C@]2([H])CC[C@@H](C)[C@]3([H])CC[C@@](O4)(C)OO[C@]32[C@]4([H])O1)CCC(O)=O
Molecular Formula
C19H28O8
Molecular Weight
384.42
Precautions
H302+H312+H332
References & Citations
[1]Ilamathi M, et al. Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma. Curr Top Med Chem. 2016;16 (22) :2453-63.|[2]Lisewski AM, et al. Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate. Cell. 2014 Aug 14;158 (4) :916-928.|[3]Wang B, et al. Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51. Cancer Biol Ther. 2015;16 (10) :1548-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
STAT3
Available Sizes
Curated Selection
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