Monepantel
Monepantel (AAD1566, NUZ-001), an antiparasitic agent, is an orally active mTOR inhibitor. Monepantel triggers autophagy through the deactivation of mTOR/p70S6K signalling pathway. Monepantel is a positive allosteric modulator of a nematode-specific clade of nAChR subunits. Monepantel can be used for the study of amyotrophic lateral sclerosis (ALS) and ovarian cancer[1][2][3][4].
Product Specifications
CAS Number
887148-69-8
Product Name Alternative
AAD1566; NUZ-001
UNSPSC
12352005
Target
Autophagy; mTOR; nAChR; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Monepantel.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N[C@@](C)(C#N)COC1=CC(C#N)=CC=C1C(F)(F)F)C2=CC=C(SC(F)(F)F)C=C2
Molecular Formula
C20H13F6N3O2S
Molecular Weight
473.39
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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