Monepantel

Monepantel (AAD1566, NUZ-001), an antiparasitic agent, is an orally active mTOR inhibitor. Monepantel triggers autophagy through the deactivation of mTOR/p70S6K signalling pathway. Monepantel is a positive allosteric modulator of a nematode-specific clade of nAChR subunits. Monepantel can be used for the study of amyotrophic lateral sclerosis (ALS) and ovarian cancer[1][2][3][4].

Product Specifications

CAS Number

[887148-69-8]

Product Name Alternative

AAD1566; NUZ-001

UNSPSC

12352005

Target

Autophagy; mTOR; nAChR; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Monepantel.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(N[C@@](C)(C#N)COC1=CC(C#N)=CC=C1C(F)(F)F)C2=CC=C(SC(F)(F)F)C=C2

Molecular Formula

C20H13F6N3O2S

Molecular Weight

473.39

References & Citations

[1]Hess J, et al. Assessment of the nematocidal activity of metallocenyl analogues of monepantel. Dalton Trans. 2016 Nov 28;45 (44) :17662-17671|[2]Bahrami F, et al. Monepantel induces autophagy in human ovarian cancer cells through disruption of the mTOR/p70S6K signalling pathway. Am J Cancer Res. 2014 Sep 6;4 (5) :558-71.|[3]Raza A, et al. Increased expression of ATP binding cassette transporter genes following exposure of Haemonchus contortus larvae to a high concentration of monepantel in vitro. Parasit Vectors. 2016 Sep 29;9 (1) :522.|[4]Stuchlikova, et al. Monepantel induces hepatic cytochromes p450 in sheep in vitro and in vivo. Chem Biol Interact. 2015 Feb 5;227:63-8.