JNK Inhibitor VIII

JNK Inhibitor VIII (TCS JNK 6o) is a c-Jun N-terminal kinases (JNK-1, -2, and -3) inhibitor with Ki values of 2 nM, 4 nM, 52 nM, respectively, and has IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively[1].

Product Specifications

CAS Number

[894804-07-0]

Product Name Alternative

TCS JNK 6o

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

JNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jnk-inhibitor-viii.html

Purity

99.58

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

N#CC1=C(N=C(NC(CC2=C(C=CC(OC)=C2)OC)=O)C=C1N)OCC

Molecular Formula

C18H20N4O4

Molecular Weight

356.38

Precautions

H302, H312, H332

References & Citations

[1]Szczepankiewicz BG, et al. Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49 (12) :3563-80.