PEN (rat)

PEN (rat), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83[1].

Product Specifications

CAS Number

[569364-13-2]

UNSPSC

12352209

Target

G protein-coupled Bile Acid Receptor 1

Type

Peptides

Related Pathways

GPCR/G Protein

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pen-rat.html

Purity

99.24

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](CCC1)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]2N(CCC2)C([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H]3N(CCC3)C(CNC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@@H](N)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C102H169N27O33

Molecular Weight

2301.59

References & Citations

[1]Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10 (4) :1884-1891.|[2]Ivone Gomes, et al. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9 (425) :ra43.