2-HBA
2-HBA is a potent inducer of NAD (P) H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.
Product Specifications
CAS Number
[131359-24-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Caspase; Quinone Reductase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-HBA.html
Purity
99.46
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(/C=C/C1=CC=CC=C1O)/C=C/C2=CC=CC=C2O
Molecular Formula
C17H14O3
Molecular Weight
266.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Dinkova-Kostova AT, et al. Bis (2-hydroxybenzylidene) acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway. Cancer Lett. 2007 Jan 8;245 (1-2) :341-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 10; Caspase 3
Available Sizes
Curated Selection
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