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2-HBA

2-HBA is a potent inducer of NAD (P) H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.

Product Specifications

CAS Number

[131359-24-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Caspase; Quinone Reductase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-HBA.html

Purity

99.46

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(/C=C/C1=CC=CC=C1O)/C=C/C2=CC=CC=C2O

Molecular Formula

C17H14O3

Molecular Weight

266.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Dinkova-Kostova AT, et al. Bis (2-hydroxybenzylidene) acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway. Cancer Lett. 2007 Jan 8;245 (1-2) :341-9.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-103667/2-HBA-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-103667/2-HBA-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Caspase 10; Caspase 3

Available Sizes

Curated Selection

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