[D-Pro4, D-Trp7,9, Nle11] Substance P (4-11)

[D-Pro4, D-Trp7,9, Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist. [D-Pro4, D-Trp7,9, Nle11] Substance P (4-11) inhibits the effects of gold-protein-substance P (GPSP) and substance P (SP) [1].

Product Specifications

CAS Number

[89430-34-2]

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/d-pro4-d-trp7-9-nle11-substance-p-4-11.html

Solubility

H2O

Smiles

CCCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CC=CC=C3)NC([C@@H](CC4=CNC5=C4C=CC=C5)NC([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@@H]6NCCC6)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C58H77N13O10

Molecular Weight

1116.31

References & Citations

[1]Cathieni M M, et al. Pharmacological Evidence that Gold-Protein-Substance P Complex Activates Neurokinin NK1 Receptors[J]. Cellular Physiology & Biochemistry, 1995, 5 (2) :85-95.