PROTAC RIPK degrader-6
PROTAC RIPK degrader-6 (example 1) is a Cereblon-based PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder[1].
Product Specifications
CAS Number
[2089205-64-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
PROTACs; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-ripk-degrader-6.html
Purity
99.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C(C(OCCOCCOCCOCCOCC(NC1=C(CN(C2C(NC(CC2)=O)=O)C3=O)C3=CC=C1)=O)=C4)=CC(C4=NC=C5)=C5NC6=CC(N=CS7)=C7C=C6)(C(C)(C)C)=O
Molecular Formula
C43H48N6O11S2
Molecular Weight
889.00
Precautions
H315, H319, H320
References & Citations
[1]John David Harlin, et al. Compounds for the modulation of rip2 kinase activity. WO2017046036A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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