Adenosine monophosphate

Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction[1][2][3].

Product Specifications

CAS Number

[61-19-8]

Product Name Alternative

AMP

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor; Endogenous Metabolite; HSV

Type

Natural Products

Related Pathways

Anti-infection; GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Adenosine_monophosphate.html

Purity

99.80

Solubility

DMSO : 16.67 mg/mL (ultrasonic) |H2O : 1.67 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N2C=NC3=C2N=CN=C3N

Molecular Formula

C10H14N5O7P

Molecular Weight

347.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Rittiner JE, et al. AMP is an adenosine A1 receptor agonist. J Biol Chem. 2012 Feb 17;287 (8) :5301-9. |[2]Zhan Y, et al. Adenosine 5'-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in mice. Cell Death Dis. 2014 Jan 9;5:e985. |[3]Ayisi NK, et al. Comparison of the antiviral effects of 5-methoxymethyldeoxyuridine-5'-monophosphate with adenine arabinoside-5'-monophosphate. Antiviral Res. 1983 Sep;3 (3) :161-74.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Human Endogenous Metabolite; Microbial Metabolite

Citation 01

Anal Chem. 2025 May 13;97 (18) :9827-9835.|Biochem Biophys Res Commun. 2024 May 14:708:149814.|Cell. 2025 Oct 30;188 (22) :6151-6169.e24.|Genes (Basel) . 2022 Dec 16;13 (12) :2384.|Mar Pollut Bull. 2025 Nov:220:118455.|MedComm (2020) . 2025 Jan 8;6 (1) :e70046.|Molecules. 2023 Apr 11;28 (8) :3375.|Molecules. 2025 Mar 9;30 (6) :1224.|Nature. 2025 Jul;643 (8070) :192-200.|Research Square Preprint. 2022 May.|Stem Cell Res Ther. 2023 Sep 29;14 (1) :277.|Stem Cell Res Ther. 2025 Jun 2;16 (1) :277.|Stem Cell Res Ther. 2025 Mar 26;16 (1) :148.|Theranostics. 2020 Aug 13;10 (22) :10245-10261. |Theranostics. 2024 Aug 12;14 (12) :4874-4893.|University of Cambridge. 2023 Feb.|J Exp Med. 2026 Jan 5;223 (1) :e20250440.