CDK5 inhibitor 20-223
CDK5 inhibitor 20-223 is a potent CDK2 and CDK5 inhibitor with IC50s of 6.0 and 8.8 nM, respectively. CDK5 inhibitor 20-223 is an effective anti-colorectal cancer (CRC) agent[1].
Product Specifications
CAS Number
[865317-30-2]
Product Name Alternative
CP668863
UNSPSC
12352005
Hazard Statement
H315, H319
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk5-inhibitor-20-223.html
Purity
99.62
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=NNC(C2CCC2)=C1)CC3=CC=C4C=CC=CC4=C3
Molecular Formula
C19H19N3O
Molecular Weight
305.37
Precautions
H315, H319
References & Citations
[1]Caroline M Robb, et al. Characterization of CDK (5) Inhibitor, 20-223 (Aka CP668863) for Colorectal Cancer Therapy. Oncotarget. 2017 Dec 28;9 (4) :5216-5232.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK5
Available Sizes
Curated Selection
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