HIF-2α-IN-2

HIF-2α-IN-2 is a hypoxia-inducible factors (HIF-2α) inhibitor extracted from patent WO2015035223A1, Compound 232, has an IC50 of 16 nM in scintillation proximity assay (SPA) [1].

Product Specifications

CAS Number

[1672666-82-8]

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hif-2-alpha-in-2.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=CC(OC2=CC=C(S(=O)(C)=O)C3=C2CC(F)C3O)=CC(F)=C1

Molecular Formula

C17H13F2NO4S

Molecular Weight

365.35

References & Citations

[1]Darryl David DIXON, et al. Aryl ethers and uses thereof. WO2015035223A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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