D-Arabinopyranose

D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059) . D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM) . D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) [1][2][3][4].

Product Specifications

CAS Number

[28697-53-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

AMPK; Bacterial; Parasite; PPAR

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d-arabinose-1.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 125 mg/mL (ultrasonic)

Smiles

OC1[C@H]([C@@H]([C@@H](CO1)O)O)O

Molecular Formula

C5H10O5

Molecular Weight

150.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Guo Y, et al. D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription. Pharmacol Res. 2024 Apr;202:107136.|[2]Sakoguchi H, et al. Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans: Discovery of a novel bioactive monosaccharide. Bioorg Med Chem Lett. 2016 Feb 1;26 (3) :726-729.|[3]LeBlanc DJ, et al. Metabolism of D-arabinose: a new pathway in Escherichia coli. J Bacteriol. 1971 Apr;106 (1) :90-6.|[4]An SJ, et al. Inhibitory effect of d-arabinose on oral bacteria biofilm formation on titanium discs. Anaerobe. 2022 Jun;75:102533.