Clobetasone butyrate

Clobetasone butyrate is a synthetic glucocorticoid and has topical anti-inflammatory activity especially in skin. Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis[1].

Product Specifications

CAS Number

[25122-57-0]

UNSPSC

12352211

Hazard Statement

H351

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/clobetasone-butyrate.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]1(C2)[C@](C(CCl)=O)(OC(CCC)=O)[C@@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)C2=O)=O

Molecular Formula

C26H32ClFO5

Molecular Weight

478.98

Precautions

H351

References & Citations

[1]Munro DD, et al. Clobetasone butyrate, a new topical corticosteroid: clinical activity and effects on pituitary-adrenal axis function and model of epidermal atrophy.|[2]Michael Stewart, et al. Clobetasone butyrate for inflammatory skin conditions.