Ethionamide

Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic with antibacterial effect and oral activity[1][2][3][4].

Product Specifications

CAS Number

[536-33-4]

Product Name Alternative

2-Ethylthioisonicotinamide

UNSPSC

12352005

Hazard Statement

H302, H361

Target

Antibiotic; Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Ethionamide.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

S=C(C1=CC(CC)=NC=C1)N

Molecular Formula

C8H10N2S

Molecular Weight

166.25

Precautions

H302, H361

References & Citations

[1]Vannelli, T.A., A. Dykman, and P.R. Ortiz de Montellano, The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase. J Biol Chem, 2002. 277 (15) : p. 12824-9.|[2]Quemard, A., G. Laneelle, and C. Lacave, Mycolic acid synthesis: a target for ethionamide in mycobacteria? Antimicrob Agents Chemother, 1992. 36 (6) : p. 1316-21.|[3]Marilyn C Henderson, et al. Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes. Toxicol Appl Pharmacol. 2008 Dec 15;233 (3) :420-7.|[4]Amy L Palmer, et al. Metabolism and pharmacokinetics of the anti-tuberculosis drug ethionamide in a flavin-containing monooxygenase null mouse. Pharmaceuticals (Basel) . 2012;5 (11) :1147-59.