Methylene blue (purity≥70%)

Methylene blue (purity≥70%) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue (purity≥70%) is a vasopressor and is often used as a dye in several medical procedures. Methylene blue (purity≥70%) through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue (purity≥70%) is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue (purity≥70%) is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation[1][2][3].

Product Specifications

CAS Number

[61-73-4]

Product Name Alternative

Basic Blue 9 (purity≥70%) ; CI-52015 (purity≥70%) ; Methylthioninium (chloride) (purity≥70%)

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Guanylate Cyclase; Microtubule/Tubulin; Monoamine Oxidase; NO Synthase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/methylene-blue-purity-70.html

Purity

95.0

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

CN(C)C1=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C2C=C1.[Cl-]

Molecular Formula

C16H18ClN3S

Molecular Weight

319.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Klamer D, et, al. Phencyclidine-induced behaviour in mice prevented by methylene blue. Basic Clin Pharmacol Toxicol. 2004 Feb;94 (2) :65-72.|[2]Hochgräfe K, et, al. Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Acta Neuropathol Commun. 2015 May 10;3:25. |[3]Fenn AM, et, al. Methylene blue attenuates traumatic brain injury-associated neuroinflammation and acute depressive-like behavior in mice. J Neurotrauma. 2015 Jan 15;32 (2) :127-38.