HCAXII-IN-10
HCAXII-IN-10 (Compound 18b) is a dual inhibitor of human carbonic anhydrase isoform XII (hCAXII) and cathepsin B, with a Ki value of 2.2 nM. hCAXII-IN-10 can inhibit the role of hCAXII in providing tumors with a pH microenvironment conducive to tumor growth, and is expected to be used in the study of tumor diseases[1].
Product Specifications
UNSPSC
12352005
Target
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaxii-in-10.html
Smiles
O=C(C1=NN(C2=CC=C(S(=O)(N)=O)C=C2)C(C3=C(C)N(C4=CC=C(C)C=C4)N=N3)=C1)N
Molecular Formula
C20H19N7O3S
Molecular Weight
437.47
References & Citations
[1]Siwach K, et al. Benzenesulfonamides functionalized with triazolyl-linked pyrazoles possess dual cathepsin B and carbonic anhydrase inhibitory action. Arch Pharm (Weinheim) . 2024 Jun 20:e2400114.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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