(S, S) -CPI-1612

(S, S) -CPI-1612 is the isomer of CPI-1612 (HY-136285), and can be used as an experimental control. CPI-1612 is a highly potent, orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with an IC50 of 8.1 nM for EP300 HAT. CPI-1612 has an anticancer activity[1].

Product Specifications

CAS Number

[2374971-82-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Histone Acetyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-s-cpi-1612.html

Purity

99.88

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CN(N=C1)C=C1C(C=N2)=CC=C2NC([C@H](C3=CC=CC=C3)NC[C@H](C4=CC=C(C=C4)C#N)C)=O

Molecular Formula

C27H26N6O

Molecular Weight

450.53

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Wang F, et al. Microstructure of poly (gamma-glutamic acid) produced by Bacillus subtilis consisting of clusters of D- and L-glutamic acid repeating units. J Agric Food Chem. 2008 Jun 11;56 (11) :4225-8.