Methyl Salicylate-d4

Methyl Salicylate-d4 is the deuterium labeled Methyl Salicylate[1]. Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products[2]. A systemic acquired resistance (SAR) signal in tobacco[3]. A topical nonsteroidal anti-inflammatory agent (NSAID) . Methyl salicylate lactoside is a COX inhibitor[5].

Product Specifications

CAS Number

[1219802-12-6]

Product Name Alternative

Wintergreen oil-d4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Purity

99.8

Solubility

10 mM in DMSO

Smiles

COC(C1=C(C([2H])=C([2H])C([2H])=C1[2H])O)=O

Molecular Formula

C8H4D4O3

Molecular Weight

156.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Greene T, et al. A critical review of the literature to conduct a toxicity assessment for oral exposure to methyl salicylate. Crit Rev Toxicol. 2017 Feb;47 (2) :98-120.|[3]Park SW, et al. Methyl salicylate is a critical mobile signal for plant systemic acquired resistance. Science. 2007 Oct 5318 (5847) :113-6.|[4]Lapczynski A, et al. Fragrance material review on methyl salicylate. Food Chem Toxicol. 200745 Suppl 1:S428-52.|[5]Xin W, et al. Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice. Br J Pharmacol. 2014 Jul171 (14) :3526-38.