SelSA
Product Specifications
UNSPSC Description
SelSA is a selective, orally active inhibitor for histone deacetylase 6 (HDAC6) with IC50 of 56.9 nM. SelSA inhibits the phosphorylation of ERK1/2. SelSA inhibits the proliferation of breast cancer cells and hepatocellular carcinoma cells with IC50 of 0.58-2.6 μM, inhibits cell migration and invasion of Huh7, and induces apoptosis. SelSA exhibits antitumor activity in mouse model[1][2].
Target Antigen
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/selsa.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#C[Se]CCCCCC(NC1=CC=CC=C1)=O
Molecular Weight
295.24
References & Citations
[1]Yang Z, et al. Histone Deacetylase 6 Inhibitor 5-Phenylcarbamoylpentyl Selenocyanide (SelSA) Suppresses Hepatocellular Carcinoma by Downregulating Phosphorylation of the Extracellular Signal-Regulated Kinase 1/2 Pathway[J]. ACS Pharmacology & Translational Science, 2024.|[2]Tang C, et al. A selenium-containing selective histone deacetylase 6 inhibitor for targeted in vivo breast tumor imaging and therapy[J]. Journal of Materials Chemistry B, 2019, 7(22): 3528-3536.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162616/SelSA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162616/SelSA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1225038-92-5
Available Sizes
Curated Selection
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