Erinacine C

Erinacine C is the inhibitor for NF-κB signaling pathway and the activator for Nrf2 signaling pathway. Erinacine C exhibits antioxidant, neuroprotective and anti-inflammatory effects[1][2].

Product Specifications

CAS Number

[156101-09-6]

UNSPSC

12352005

Target

Heme Oxygenase (HO) ; Keap1-Nrf2; NF-κB

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/erinacine-c.html

Purity

98.61

Solubility

Ethanol : 10 mg/mL (ultrasonic; warming)

Smiles

C[C@]12C([C@]3([H])[C@]([C@]4([H])[C@@](O[C@@]5([H])[C@](OC[C@H]([C@@H]5O)O)([H])O4)([H])C(CO)=CC3)(CC1)C)=C(CC2)C(C)C

Molecular Formula

C25H38O6

Molecular Weight

434.57

References & Citations

[1]Hiromichi Kenmoku, et al. Erinacine Q, a new erinacine from Hericium erinaceum, and its biosynthetic route to erinacine C in the basidiomycete. Biosci Biotechnol Biochem. 2002 Mar;66 (3) :571-5. |[2]Wang LY, et al., Anti-Inflammatory Effect of Erinacine C on NO Production Through Down-Regulation of NF-κB and Activation of Nrf2-Mediated HO-1 in BV2 Microglial Cells Treated with LPS. Molecules. 2019 Sep 12;24 (18) :3317.|[3]Lee KF, et al., The Cerebral Protective Effect of Novel Erinacines from Hericium erinaceus Mycelium on In Vivo Mild Traumatic Brain Injury Animal Model and Primary Mixed Glial Cells via Nrf2-Dependent Pathways. Antioxidants (Basel) . 2024 Mar 19;13 (3) :371.