PROTAC IRAK4 degrader-1
PROTAC IRAK4 degrader-1 (compound I-210) is a Cereblon-based IRAK4 PROTAC. PROTAC IRAK4 degrader-1 is composed of IRAK4 ligand (red part) PROTAC IRAK4 ligand-1 (HY-129967), E3 ligase ligand (blue part) Pomalidomide (HY-10984), and PROTAC linker (black part) AM-Imidazole-PA-Boc (HY-129968) [1].
Product Specifications
CAS Number
[2360533-90-8]
UNSPSC
12352005
Target
IRAK; PROTACs
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-irak4-degrader-1.html
Purity
99.77
Solubility
DMSO : 180 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(N2C=C(NC(C3=COC(C4=CC=NC(NCC5CC5)=C4)=N3)=O)C(C(F)(F)F)=N2)C=C1)NCCCN(C=N6)C=C6CNC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8=O)=O)=CC=C7
Molecular Formula
C44H39F3N12O7
Molecular Weight
904.85
References & Citations
[1]Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; IRAK4
Available Sizes
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