1-Pyrenebutyric acid N-hydroxysuccinimide ester

1-Pyrenebutyric acid N-hydroxysuccinimide ester (PANHS) is a linker and interface coupling agent that can be used to prepare electrochemical biosensors. 1-Pyrenebutyric acid N-hydroxysuccinimide ester immobilizes SARS-CoV-2 spike antibodies on graphene sheets. 1-Pyrenebutyric acid N-hydroxysuccinimide ester is often used as an activation reagent for carboxylic acids in organic chemistry or biochemistry[1][2][3][4][5][6].

Product Specifications

CAS Number

[114932-60-4]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Biochemical Assay Reagents; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/1-pyrenebutyric-acid-n-hydroxysuccinimide-ester.html

Purity

99.93

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(ON1C(CCC1=O)=O)CCCC2=C(C3=C45)C=CC5=CC=CC4=CC=C3C=C2

Molecular Formula

C24H19NO4

Molecular Weight

385.41

Precautions

H315, H319, H335

References & Citations

[1]Benvidi A, et al. Comparison of impedimetric detection of DNA hybridization on the various biosensors based on modified glassy carbon electrodes with PANHS and nanomaterials of RGO and MWCNTs. Talanta. 2016 Jan 15;147:621-7. |[2]Tian J, et al. Biosensing platform based on graphene oxide via self-assembly induced by synergic interactions. Anal Biochem. 2014 Sep 1;460:16-21.|[3]Stefansson S, et al. Targeting antibodies to carbon nanotube field effect transistors by pyrene hydrazide modification of heavy chain carbohydrates[J]. Journal of Nanotechnology, 2012, 2012 (1) : 490175.|[4]Fapyane D, et al. Graphitized-Carbon-Nanofiber Paper-Enzyme Electrode Fabrication Through Non-Covalent Modification for Enzyme Biofuel Cell Application. J Biomed Nanotechnol. 2015 Jan;11 (1) :137-42.|[5]Khandelwal V, et al. Graphene biosensor: Rapid and Accurate diagnostic method of COVID-19 (SARS-CoV-2) . 2020.|[6]Sakamoto H, et al. Development of biofuel cell using a complex of highly oriented immobilized his-tagged enzyme and carbon nanotube surface through a pyrene derivative. Journal of Nanoscience and Nanotechnology, 2019, 19 (6) : 3551-3557.